Brufen 400 mg tablets belong to a group of medicines called Non steroidal anti-inflammatory drugs. They can be used to relieve pain and inflammation in conditions such as osteoarthritis rheumatoid arthritis (including juvenile rheumatoid arthritis) arthritis of the spine ankylosing spondylitis swollen joints frozen shoulder bursitis tendonitis tenosynovitis lower back pain sprains and strains. Brufen can also be used to treat other painful conditions such as toothache pain after operations period pain and headache including migraine. The effect of Brufen is due to an inhibition of prostaglandins. They can cause pain fever and inflammation. If no prostaglandins are produced pain fever and inflammation disappear. The actual causes of pain such as inflammatory processes are combated on the spot.