HYALO4 Plus cream is a topical preparation constituted by hyaluronic acid sodium salt as its principal component. Hyaluronic acid is a biological polysaccharide (glycosaminoglycan) distributed in the extracellular matrix of most tissues. Several studies have documented that it may participate in many and diverse tissue repair processes facilitating healing and re-epithelialization. Due to its hydrophilic properties, it provides a moist wound environment necessary to the natural healing process. Silver sulfadiazine is a well-known anti-microbial agent inhibiting the growth in vitro of nearly all pathogenic bacteria and fungi. The presence of silver sulfadiazine in the product composition plays a role in preventing the microbial contamination, thus improving the hyaluronic acid ability to support wound healing. These characteristics allow to change the dressing even only once a day: this causes the minimum discomfort to the patient and the minimum exposure of the lesion to the air, thus reducing the possibility of wound contamination.